Association studies of the CT repeat polymorphism in the 5 ' upstream region of the cholecystokinin B receptor gene with panic disorder and schizophrenia in Japanese subjects
E. Hattori et al., Association studies of the CT repeat polymorphism in the 5 ' upstream region of the cholecystokinin B receptor gene with panic disorder and schizophrenia in Japanese subjects, AM J MED G, 105(8), 2001, pp. 779-782
The tetrapeptide of cholecystokinin (CCK), CCK-4, is known to induce panic
attacks in human subjects, while CCK-8 is reported to have a therapeutic ef
fect on schizophrenia symptoms. Recently, we have identified a novel micros
atellite polymorphism in the 5' upstream region of the CCK gene and shown a
significant association between this polymorphism and panic disorder. In t
his study, we have investigated the CCK-B receptor (CCKBR) gene, which is t
he main constituent of the CCK receptor in the CNS. Recently, a dinucleotid
e repeat, (CT)(n), in the 5' regulatory region of the CCKBR gene was report
ed to be associated with panic disorder in Canadian samples. To evaluate an
association of the CT repeat with panic disorder and schizophrenia, we gen
otyped 71 subjects with panic disorder, 154 schizophrenics and 199 controls
. However, no evidence of allelic association was found between the polymor
phic repeat of the CCKBR gene and either panic disorder or schizophrenia (P
=0.186 and 0.987, respectively). Together with the negative reports on asso
ciation analyses using other polymorphisms of the CCKBR gene and Japanese s
amples, the present results exclude a major genetic contribution of the CCK
BR gene to susceptibilities to panic disorder and schizophrenia in Japanese
cohorts. (C) 2001 Wiley-Liss, Inc.