B. Arias et al., The 5-HT2A receptor gene 102T/C polymorphism is associated with suicidal behavior in depressed patients, AM J MED G, 105(8), 2001, pp. 801-804
Several lines of evidence suggest that genetic factors constitute an import
ant determinant of suicidal behavior. A significant association between the
5-HT2A-C allele and suicidality has recently been reported. The aim of thi
s study was to investigate whether the proposed association between 5-HT2A-
102T/C polymorphism and suicidality could be replicated in a larger and ind
ependent sample of Spanish patients with major depression. The 102T/C polym
orphism of the 5-HT2A receptor gene was analyzed in 159 patients with major
depression (DSM-IV criteria) and 164 unrelated and healthy controls using
a case control design. All individuals were subjects of Spanish origin. Sig
nificant differences in allele (chi-square = 4.13, df = 1, P = 0.04) and ge
notype (chi-square = 6.19, df = 2, P = 0.04) distributions were found betwe
en non-suicide attempters and suicide attempters. Moreover, those patients
carrying 5-HT2A-C allele had more than five times the risk for attempting s
uicide than noncarriers (OR = 5.50, 95% CI = 1.18-35.20, P = 0.01). Our res
ults replicate the proposed association between 5HT(2A)-C allele and suicid
ality in major depression. Moreover, no overall associations are detected w
hen patients with major depression and controls are compared for 102T/C fre
quencies, suggesting that the increased risk for suicidality conferred by 5
-HT2A-C allele is primarily associated with suicidal behavior and not with
the diagnosis of major depression itself. (C) 2001 Wiley-Liss, Inc.