Use of an intravitreal sustained-release cyclosporine delivery device for treatment of equine recurrent uveitis

Objective-To evaluate the use of an intravitreal sustained-release cyclospo rine (CsA) delivery device for treatment of horses with naturally occurring recurrent uveitis. Animals-16 horses with recurrent uveitis. Procedures-Horses with frequent recurrent episodes of uveitis or with disea se that was progressing despite appropriate medication were selected for th is study. Additional inclusion criteria included adequate retinal function as determined by use of electroretinography, lack of severe cataract format ion, and no vision-threatening ocular complications (eg, retinal detachment , severe retinal degeneration, and posterior synechia). Sustained-release C sA delivery devices (4 mug of CsA/d) were implanted into the vitreous throu gh a sclerotomy at the pars plana. Reexaminations were performed 1, 3, 6, a nd 12 months after implantation, then continued annually, Ophthalmic change s, number of recurrent episodes of uveitis, and vision were recorded. Results-The rate of recurrent episodes after device implantation (0.36 epis odes/y) was less than prior to surgery (7.5 episodes/y). In addition, only 3 horses developed episodes of recurrent uveitis after surgery. Vision was detected in 14 of 16 affected eyes at a mean follow-up time of 13.8 months (range, 6 to 24 months). Conclusions and Clinical Relevance-This intravitreal sustained-release CsA delivery device may be a safe and important tool for long-term treatment of horses with chronic recurrent uveitis.