Severe polymorphous pustular vasculitis induced by losartan

Introduction. We report a case of severe pustular vasculitis most probably due to losartan (Cozaar (R)) which is an antihypertensive drug inhibiting t he receptors for angiotensin II, Case report. A 64-year-old woman, suffering from hypertension, developped a widespread and rapidly evolving bullous and pustular eruption without any other clinical sign, Leucocytoclastic vasculitis and junctional blisters we re present with deposits of both IgA and IgG at these sites, Withdrawal of losartan, which was the only drug taken by the patient, and tapered cortico therapy cleared the lesions. The rash left a prominent mottled hyperpigment ation, It did not recur during the following months despite the presence of antineutrophil cytoplasmic antibodies, Discussion. So far only a few cutaneous side effects have been reported fol lowing losartan intake, This drug was the likely culprit in the present cas e, Vasculitis was extremely severe and polymorphous.