Synthesis and antifungal activity of 3,3 '-ethylenebis(5-alkyl-1,3,5-thiadiazine2-thiones)

In a search for promising antifungal compounds, nine new 3,3'-ethylenebis(5 -alkyl-1,3,5-thiadiazine-2-thiones) were synthesized by the reaction of eth ylene diamine, carbon disulfide, formaldehyde, and the appropriate alkyl am ine. The title compounds were tested for their antifungal activity in vitro against pathogenic (Trichophyton rubrum and Candida albicans), phytopathog enic (Penicillum expansum, Trichoderma hazianum, and Fasarium oxysporum), a nd aflatoxin producing (Aspergillus flavus) fungi. These compounds exhibite d varied inhibitory effects on growth or sporulation of some tested fungal species.