PRIMARY LIVER-CANCER IN 2 SISTERS IN HOLLAND WITH INTERMITTENT ACUTE PORPHYRIA

Two sisters living in Holland, with a niece now living in South Africa , were reported in 1958 to have inherited intermittent acute porphyria (IAP), In 1994 both sisters died from primary liver cancer, Other rep orts have also noted an increased mortality from carcinoma of the live r in porphyrics. Porphyria variegata has a high prevalence in white an d coloured South Africans, and it would be relatively easy to ascertai n whether those who have inherited the gene for this disorder, in Sout h Africa, have a higher than reported mortality from liver cancer. If they do, consideration should be given to ways to reduce their risk of developing and dying from this cancer.