In vitro response of macrophages to a new carbon-polylactide composite forthe treatment of periodontal diseases

The purpose of the study was to examine the response of macrophages and the concentration of selected released cytokines following contact with a new carbon-polylactide composite. The macrophages were grown on samples of the materials and on each of its components separately. Viability of the cells as well as concentrations of interleukins IL-6, IL-10, IL-12 and TNF-alpha were then determined. Sonic differences in the viability of the cells were demonstrated. They varied according to the kind of material used. After inc ubation with the serum, the composite and its components induced the releas e of IL-6, IL-12 and TNF-a which did not differ significantly from one anot her. (C) 2001 Elsevier Science Ltd. All rights reserved.