Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection

Authors
Kim, D Wang, LP Caldwell, CG Chen, P Finke, PE Oates, B MacCoss, M Mills, SG Malkowitz, L Gould, SL DeMartino, JA Springer, MS Hazuda, D Miller, M Kessler, J Danzeisen, R Carver, G Carella, A Holmes, K Lineberger, J Schleif, WA Emini, EA
Citation
D. Kim et al., Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection, BIOORG MED, 11(24), 2001, pp. 3099-3102
Citations number
25
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
24
Year of publication
2001
Pages
3099 - 3102
Database
ISI
SICI code
0960-894X(200112)11:24<3099:DOHCAC>2.0.ZU;2-Q
Abstract
A series of hydantoin derivatives has been discovered as highly potent nonp eptide antagonists for the human CCR5 receptor. The synthesis. SAR. and bio logical profiles of this class of antagonists are described. (C) 2001 Elsev ier Science Ltd. All rights reserved.