Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers

Authors
Padmanabhan, S Lavin, RC Thakker, PM Guo, JQ Zhang, L Moore, D Perlman, ME Kirk, C Daly, D Burke-Howie, KJ Wolcott, T Chari, S Berlove, D Fischer, JB Holt, WF Durant, GJ McBurney, RN
Citation
S. Padmanabhan et al., Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers, BIOORG MED, 11(24), 2001, pp. 3151-3155
Citations number
26
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
24
Year of publication
2001
Pages
3151 - 3155
Database
ISI
SICI code
0960-894X(200112)11:24<3151:SPSAPE>2.0.ZU;2-1
Abstract
Solution-phase synthesis of various acylguanidine derivatives and the evalu ation of a small library Of Compounds as potential sodium channel blockers are described. (C) 2001 Elsevier Science Ltd. All rights reserved.