Biological activity in human neutrophils of di-tripeptides, analogues of the chemotactic fMLP

Authors
Cavicchioni, G Turchetti, M Spisani, S
Citation
G. Cavicchioni et al., Biological activity in human neutrophils of di-tripeptides, analogues of the chemotactic fMLP, BIOORG MED, 11(24), 2001, pp. 3157-3159
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
24
Year of publication
2001
Pages
3157 - 3159
Database
ISI
SICI code
0960-894X(200112)11:24<3157:BAIHNO>2.0.ZU;2-I
Abstract
for-Met-Ser(for-Met-Leu-Phe)-Phe-OMe 1 and for-Met-Lys(for- Met- Leu- Phe)- Phe-OMe 2 were synthesized in order to investigate biological activities on human neutrophils of crosslinked di-tripeptides. Our results seem to highl ight that the tested di-tripeptides (i) do not step up chemotaxis. (ii) can elicit superoxide anion production which is dependent on the nature of the residue at position 2, chosen in the tripeptide that is crosslinked to the fMLP-OMe. (C) 2001 Elsevier Science Ltd. All rights reserved.