Allogeneic stem cell transplantation for Evans syndrome

Evans syndrome is a rare disorder characterized by combined autoimmune thro mbocytopenia (ITP) and autoimmune hemolytic anemia (AIHA). Standard treatme nts consist of transfusions, corticosteroids, splenectomy, IVIG, anabolic s teroids, vincristine, alkylating agents, or cyclosporine. In a patient with refractory disease, an allogeneic hematopoietic stem cell transplant (HSCT ) resulted in complete clinical and serologic remission for more than 30 mo nths. Allogeneic HSCT may be the only current curative therapy for Evans sy ndrome but may also be complicated by significant toxicities.