PREPARATIVE SEPARATION OF ENANTIOMERS USING HOLLOW-FIBER MEMBRANE TECHNOLOGY

Authors
PIRKLE WH BOWEN WE
Citation
Wh. Pirkle et We. Bowen, PREPARATIVE SEPARATION OF ENANTIOMERS USING HOLLOW-FIBER MEMBRANE TECHNOLOGY, Tetrahedron : asymmetry, 5(5), 1994, pp. 773-776
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
5
Issue
5
Year of publication
1994
Pages
773 - 776
Database
ISI
SICI code
0957-4166(1994)5:5<773:PSOEUH>2.0.ZU;2-Z
Abstract
Several chromatographically developed chiral selectors show promise fo r large scale separation of enantiomers using hollow-fiber membrane te chnology. Chiral selectors derived from N(1-naphthyl)leucine have been used in a hollow-fiber membrane system (Sepracor) to separate the ena ntiomers of amino acid derivatives. Enantiomeric purities exceeding 95 % have been obtained in a single pass through the system For data coll ection, sample sizes were limited to gram quantities of racemate.