3-benzamido, ureido and thioureidoimidazo[1,2-a]pyridine derivatives as potential antiviral agents

This work reports the synthesis and the antiviral activities of 3-benzamido , 3-phenylureido and 3-phenyl-thioureido derivatives in the imidazo[1,2-a]p yridine series. The structure was proven by NMR spectroscopy. The synthesiz ed compounds were evaluated against a large number of viruses. The 3-phenyl thioureido derivative 7 showed moderate activity against human cytomegalovi rus (HCMV) in vitro. The crystallographic data for 8 are also reported and explain the absence of activity against human immunodeficiency virus (HIV).