Synthesis of 2-O-(4-coumaroyl)-3-(4-hydroxyphenyl)lactic acid, an important intermediate of rosmarinic acid biosynthesis

Authors
Matsuno, M Nagatsu, A Ogihara, Y Mizukami, H
Citation
M. Matsuno et al., Synthesis of 2-O-(4-coumaroyl)-3-(4-hydroxyphenyl)lactic acid, an important intermediate of rosmarinic acid biosynthesis, CHEM PHARM, 49(12), 2001, pp. 1644-1646
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
49
Issue
12
Year of publication
2001
Pages
1644 - 1646
Database
ISI
SICI code
0009-2363(200112)49:12<1644:SO2AAI>2.0.ZU;2-4
Abstract
A simple method to synthesize (+/-)-2-O-(4-coumaroyl)-3-(4-hydroxyphenyl)la ctic acid (1), a key intermediate in rosmarinic acid biosynthesis in higher plant cells, was established by condensation of protected 4-coumaric acid and (+/-)-3-(4-hydroxyphenyl)lactic acid followed by deprotection. A stable supply of 1 thus attained will lead to biochemical and molecular biologica l characterization of later steps of rosmarinic acid biosynthesis.