Synthesis and antibacterial activity of new 1 beta-methylcarbapenems having the potential for intramolecular nonbonded S center dot center dot centerdot O interactions

Authors
Nagao, Y Iimori, H Nam, KH Sano, S Shiro, M
Citation
Y. Nagao et al., Synthesis and antibacterial activity of new 1 beta-methylcarbapenems having the potential for intramolecular nonbonded S center dot center dot centerdot O interactions, CHEM PHARM, 49(12), 2001, pp. 1660-1661
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
49
Issue
12
Year of publication
2001
Pages
1660 - 1661
Database
ISI
SICI code
0009-2363(200112)49:12<1660:SAAAON>2.0.ZU;2-7
Abstract
Mercaptoacetyliminothiadiazoline derivatives (19, 20) useful for the pendan t moiety of 1 beta -methylcarbapenem antibiotics were efficiently synthesiz ed. Acetyl derivative (18) of 20 was submitted to X-ray analysis, and a sig nificant nonbonded S . . .O close contact was recognized in the crystallogr aphic structure. New 1 beta -methylcarbapenems (5, 6) were synthesized by e xploiting 19 and 20, and exhibited considerable antibacterial activities in vitro.