A surprisingly mild and versatile method for palladium-catalyzed Suzuki cross-couplings of aryl chlorides in the presence of a triarylphosphine

In the presence of new air-stable triarylphosphine 2, palladium-catalyzed S uzuki reactions of a wide array of aryl chlorides can be accomplished in un iformly good yield, including couplings of very sterically demanding and el ectronically deactivated substrates; activated aryl chlorides can be couple d at room temperature. In terms of scope and mildness, Pd-2 compares well w ith other catalyst systems that have been described for Suzuki reactions of aryl chlorides, thereby establishing that triarylphosphines should be rega rded as fertile ground for future ligand-design efforts for palladium-catal yzed couplings of aryl chlorides.