Multilayer vs. monolayer amniotic membrane transplantation for deep corneal ulcer treatment

The purpose of the study was to evaluate the efficacy of multilayer amnioti c transplantation (AMT) for reconstruction of corneal stroma and epithelium . Corneal ulcer (28) was alpha consequence of a previous infectious or neur otrophic keratitis. In the first group (17) ulcer was covered with monolaye r AM, while in the other group (11) there were two or more layers of AM sit uated in the ulcer and the whole cornea was covered with AM sheet. Monolaye r AMT was successful in 64% while the multilayer AMT success rate was 72%. AM gradually dissolved within 3-6 postoperative weeks. AM transplantation f acilitates rapid healing of corneal epithelium, reduces inflammation and st imulates epithelial cell regrowth. In eyes with deep corneal ulcer multilay er technique proved to be better then monolayer procedure.