AN ASYMMETRIC-SYNTHESIS OF ISOPODOPHYLLOTOXIN

Authors
PELTER A WARD RS LI QR PIS J
Citation
A. Pelter et al., AN ASYMMETRIC-SYNTHESIS OF ISOPODOPHYLLOTOXIN, Tetrahedron : asymmetry, 5(5), 1994, pp. 909-920
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
5
Issue
5
Year of publication
1994
Pages
909 - 920
Database
ISI
SICI code
0957-4166(1994)5:5<909:AAOI>2.0.ZU;2-1
Abstract
(-)-Isopodophyllotoxin has been synthesised by a route involving an as ymmetric Diels Alder reaction between (5R)-menthyloxy-2(5H)-furanone a nd an arylisobenzofuran. Raney nickel reduction of the major adduct af fords 10-menthyloxyisopicropodophyllin which is converted into (-)-iso podophyllotoxin.