X-ray diffraction and electron microscopy in the polymorphism study of ondansetron hydrochloride

Using different techniques, we studied the possible formation of ondansetro n polymorphs. Ondansetron is a carbazol antiemetic that acts as a competiti ve, selective inhibitor of 5-HT3 serotonin receptors. The polymorphs were d etermined by X-ray diffraction (XRD) and scanning electron microscopy (SEM) . The results suggest that the compounds are not true crystallographic poly morphs, but instead are the product of physical structural changes in the d rug, which would be of interest pharmaceutically.