Experiments were conducted to determine the influence of the specific ORL1
receptor agonist, nociceptin, on the cough reflex in the cat. Cats were ane
sthetized and allowed to breathe spontaneously. Cough was elicited by mecha
nical stimulation of the intrathoracic airway. Intravenous administration o
f nociceptin (0.001-3.0 mg kg(-1)) inhibited cough number and the magnitude
of abdominal muscle electromyogram (EMG) discharge during cough in a dose-
dependent manner. Nociceptin had no effect on the magnitude of the inspirat
ory muscle EMG during cough. These effects of nociceptin were antagonized-b
y pretreatment with the ORL1 receptor antagonist, 1-[(3R,4R)-1-cyclooctylme
thyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1, 3-dihydro-2H-benzimidazol-2-on
e (J-113397, 0.1 mg kg(-1), i.v.). We conclude that intravenous nociceptin
inhibits cough in the cat. (C) 2001 Elsevier Science B.V. All rights reserv
ed.