Desmoid tumours

Desmoid tumours exhibit fibroblastic proliferation and arise from fascial o r musculoaponeurotic structures. Despite their benign microscopic appearanc e, and their negligible metastatic potential, the propensity of desmoid tum ours for local infiltration is potentially significant in terms of deformit y, morbidity and mortality due to pressure effects and obstruction of vital structures and organs. The rarity of desmoid tumours, coupled with the var iability in their clinical course, renders these lesions a vexing entity, a nd makes demonstration of the efficacy of any specific intervention difficu lt. Failure to recognize the potential for malignant behaviour in this tumo ur renders desmoids susceptible to inadequate treatment. This distinct path ological entity is reviewed with a specific focus on aetiology and treatmen t. (C) 2001 Harcourt Publishers Ltd.