ANTIRETROVIRAL EFFECTS OF NONDERIVATIZED C-60 IN-VITRO

Authors
NACSA J SEGESDI J GYURIS A BRAUN T RAUSCH H BUVARIBARCZA A BARCZA L MINAROVITS J MOLNAR J
Citation
J. Nacsa et al., ANTIRETROVIRAL EFFECTS OF NONDERIVATIZED C-60 IN-VITRO, Fullerene science and technology, 5(5), 1997, pp. 969-976
Citations number
8
Categorie Soggetti
Chemistry Physical","Physics, Atomic, Molecular & Chemical","Material Science
Journal title
Fullerene science and technology → ACNP
ISSN journal
1064122X
Volume
5
Issue
5
Year of publication
1997
Pages
969 - 976
Database
ISI
SICI code
1064-122X(1997)5:5<969:AEONCI>2.0.ZU;2-1
Abstract
We have observed that nonderivatized C-60 (buckminsterfullerene) could inhibit the replication of simian immunodeficiency virus (SIV) in vit ro and the activity of Moloney murine leukemia virus (M-MuLV) reverse transcriptase (RT) (IC50 approximate to 3 mu M). This means that biolo gical effects are exerted via a direct and active interaction of the C -60 Skeleton with other macromolecules.