ANTITUMOR EFFECT OF POLY(ETHYLENE GLYCOL)MODIFIED FULLERENE

Authors
TABATA Y MURAKAMI Y IKADA Y
Citation
Y. Tabata et al., ANTITUMOR EFFECT OF POLY(ETHYLENE GLYCOL)MODIFIED FULLERENE, Fullerene science and technology, 5(5), 1997, pp. 989-1007
Citations number
29
Categorie Soggetti
Chemistry Physical","Physics, Atomic, Molecular & Chemical","Material Science
Journal title
Fullerene science and technology → ACNP
ISSN journal
1064122X
Volume
5
Issue
5
Year of publication
1997
Pages
989 - 1007
Database
ISI
SICI code
1064-122X(1997)5:5<989:AEOPGF>2.0.ZU;2-V
Abstract
Water-insoluble fullerene (C-60) was chemically modified with poly(eth ylene glycol) (PEG) to solubilize it in water. The C-60-PEG conjugates , upon injecting intravenously, were accumulated in the tumor to a gre ater extent than in the normal tissue and exhibited prolonged C-60 ret ention at the tumor tissue. Conjugate injection followed by light irra diation significantly suppressed the volume increase of tumor. We conc lude that the PEG-modified C-60 has a high potentiality as a drug of p hotodynamic tumor therapy.