Prognostic significance of cardiac I-123 metaiodobenzylguanidine imaging for mortality and morbidity in patients failure: a prospective with chronic heart study
H. Ogita et al., Prognostic significance of cardiac I-123 metaiodobenzylguanidine imaging for mortality and morbidity in patients failure: a prospective with chronic heart study, HEART, 86(6), 2001, pp. 656-660
Citations number
25
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Objective-To determine whether cardiac iodine-123 metaiodobenzylguanidine (
I-123 MIBG) imaging is useful in predicting the prognosis of patients with
chronic heart failure.
Design-Cardiac I-123 MIBG imaging was done on entry to the study. The cardi
ac MIBG washout rate was calculated from anterior chest view images obtaine
d 20 and 200 minutes after injection of the isotope. Study patients were di
vided into two groups with washout rates above and below 27% (the mean valu
e + 2 SD obtained in 20 normal subjects), and were then followed up.
Setting-Tertiary referral centre.
Patients-79 patients with chronic heart failure in whom the left ventricula
r ejection fraction was less than 40%.
Results-There were 37 patients in group 1 (washout rate of greater than or
equal to 27%) and 42 in group 2 (< 27%). During a follow up period of betwe
en 1 and 52 months, eight patients died suddenly and five died of worsening
heart failure in group 1, while none died in group 2; 13 patients in group
1 and four in group 2 were admitted to hospital for progressive heart fail
ure. Kaplan-Meier analysis showed that group 1 had a significantly higher m
ortality and morbidity (p = 0.001 and p < 0.001, respectively) than group 2
.
Conclusions-Cardiac I-123 MIBG washout rate seems to be a good predictor of
prognosis in patients with chronic heart failure.