Effects of the quantity of water and milk ingested concomitantly with AS-924, a novel ester-type cephem antibiotic, on its pharmacokinetics

The effect of the quantity of water ingested concomitantly with drugs, on t he absorption of AS-924, a novel prodrug-type cephem antibiotic, was studie d in five healthy adult volunteers by a cross-over method, using cefteram-p ivoxil (CTER-PI) as the control drug. In addition, the effect of milk on th e absorption of AS-924 was also investigated. The absorption of CTER-PI was significantly reduced when administered together with 30 ml of water compa red with its absorption when administered together with 150 ml of water, wh ereas no such reduction was found in the case of AS-924. Ingestion of milk did not significantly affect the absorption of AS-924. These results confir m that absorption of AS-924 after oral administration is not likely to be a ffected by the quantity of water taken concomitantly with the drug, nor by milk. (C) 2001 Published by Elsevier Science B.V. and International Society of Chemotherapy.