N-heterocyclic derivatives of 2,4-dihydroxybenzcarbothioamide as antimycotic agents

N-heterocyclic derivatives of 2,4-dihydroxybenzcarbothioamide were synthesi zed from sulfinylbis(2,4-dihydroxybenzenethioyl) and commercially available heterocyclic amines. The composition and chemical structures were confirme d by IR, H-1 NMR, EI-MS, and elemental analysis. For the estimation of pote ntial activity in vitro the MIC values against 15 strains of dermatophytes, yeasts, and molds were determined. The strongest fungistatic potency was f ound for N-5 '-(3 ' -oxobenzfurylidyne)-2,4-dihydroxybenzcarbothioamide in relation to all tested dermatophyte strains with MIC = 0.48-0.98 mug/mL, On the basis of the spectroscopic data the influence of N-heterocyclic substi tution on antimycotic activity is discussed.