Chlorogentisylquinone, a new neutral sphingomyelinase inhibitor, produced by a marine fungus

Authors
Uchida, R Tomoda, H Arai, M Omura, S
Citation
R. Uchida et al., Chlorogentisylquinone, a new neutral sphingomyelinase inhibitor, produced by a marine fungus, J ANTIBIOT, 54(11), 2001, pp. 882-889
Citations number
19
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
54
Issue
11
Year of publication
2001
Pages
882 - 889
Database
ISI
SICI code
0021-8820(200111)54:11<882:CANNSI>2.0.ZU;2-1
Abstract
Chlorogentisylquinone, a new inhibitor of neutral sphingomyelinase activity , was purified from the culture broth of a fungal strain FOM-8108 isolated from a marine environment by solvent extraction, silica gel chromatography and Sephadex LH-20 chromatography. Its chemical structure was elucidated by spectroscopic studies including H-1, C-13, DEPT, HMQC and HMBC NMR experim ents. Chlorogentisylquinone inhibited neutral sphingomyelinase activity of rat brain membranes with an IC50 value of 1.2 mum.