New pyrrolizidinone antibiotics CJ-16,264 and CJ-16,367

Authors
Sugie, Y Hirai, H Kachi-Tonai, H Kim, YJ Kojima, Y Shiomi, Y Sugiura, A Sugiura, A Suzuki, Y Yoshikawa, N Brennan, L Duignan, J Huang, LH Sutcliffe, J Kojima, N
Citation
Y. Sugie et al., New pyrrolizidinone antibiotics CJ-16,264 and CJ-16,367, J ANTIBIOT, 54(11), 2001, pp. 917-925
Citations number
16
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
54
Issue
11
Year of publication
2001
Pages
917 - 925
Database
ISI
SICI code
0021-8820(200111)54:11<917:NPACAC>2.0.ZU;2-5
Abstract
Two new antibiotics, CJ-16,264 (I) and CJ-16,367 (II), were isolated from t he fermentation broth of an unidentified fungus CL39457. These antibiotics have a pyrrolizidinone skeleton, first discovered in fungi. Compounds I and II inhibit the growth of Gram-positive multi-drug resistant bacteria and s ome Gram-negative strains such as Moraxella catarrhalis and Escherichia col i with altered permeability (imp). Comparison of an antibacterial profile b etween the two compounds suggested that the gamma-lactone portion of I is i mportant for the activity.