Pentafluoropyridine was used as the starting material for the preparation o
f a range of pyridine derivatives that bear five different substituents. In
this context, syntheses of penta-functional pyridine systems by sequences
of nucleophilic aromatic substitution, palladium catalysed coupling and bro
mo-lithiation processes are described. (C) 2001 Elsevier Science BN. All ri
ghts reserved.