Sl. Wu et al., New polyoxygenated briarane diterpenoids, briaexcavatolides O-R, from the gorgonian Briareum excavatum, J NAT PROD, 64(11), 2001, pp. 1415-1420
Four new polyoxygenated briarane-type diterpenoids, briaexcavatolides O-R (
1-4), have been isolated from a gorgonian octocoral Briareum excavatum. The
ir structures were determined using spectroscopic and chemical methods. Met
abolites 1-3 were found to contain oxygenated substituents at C-2, C-3, and
C-4, and the relative configurations were assigned as 2R*,3R*,4R* at these
three positions. Briaranes containing this type of stereo chemistry are re
ported for the first time. The structures of metabolites 1 and 2 were furth
er confirmed by single-crystal X-ray analyses. Compound 2 has been shown to
exhibit significant cytotoxicity toward P-388 and HT-29 cancer cells.