Inhibition of Mycobacterium tuberculosis growth by saringosterol from Lessonia nigrescens

Authors
Wachter, GA Franzblau, SG Montenegro, G Hoffmann, JJ Maiese, WM Timmermann, BN
Citation
Ga. Wachter et al., Inhibition of Mycobacterium tuberculosis growth by saringosterol from Lessonia nigrescens, J NAT PROD, 64(11), 2001, pp. 1463-1464
Citations number
12
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
64
Issue
11
Year of publication
2001
Pages
1463 - 1464
Database
ISI
SICI code
0163-3864(200111)64:11<1463:IOMTGB>2.0.ZU;2-S
Abstract
Assay-guided fractionation of an antitubercular extract obtained from Lesso nia nigrescens yielded the phytosterol saringosterol as its active componen t. No appreciable toxicity against Vero cells was observed for this compoun d. Saringosterol was also synthesized by oxidation of facosterol. The MIC v alues for antitubercular activity of saringosterol and its 24S and 24R epim ers were determined as 0.25, 1, and 0.125 mug/mL.