Cacofurans A and B, new furanoditerpenes from a marine sponge

Authors
Tanaka, J Marriott, G Higa, T Higa, T
Citation
J. Tanaka et al., Cacofurans A and B, new furanoditerpenes from a marine sponge, J NAT PROD, 64(11), 2001, pp. 1468-1470
Citations number
11
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
64
Issue
11
Year of publication
2001
Pages
1468 - 1470
Database
ISI
SICI code
0163-3864(200111)64:11<1468:CAABNF>2.0.ZU;2-7
Abstract
Two new labdane-class diterpenes, cacofurans A (1) and B (2), have been iso lated from a sponge Cacospongia sp. Their structures were determined by ana lyzing spectroscopic data, by chemical transformations, and by X-ray diffra ction. Cacofurans I and 2 inhibited the development of fertilized sea urchi n eggs at concentrations of 0.5 and 5 mug/mL and showed an actin-disrupting effect on the NBT-II cell line at 10 mug/mL.