Synthesis of both enantiomers of altholactone, isoaltholactone and 5-hydroxygoniothalamin from tri-O-acetyl-D-glucal, and their biological activities

Both enantiomers of altholactone, isoaltholactone and 5-hydroxygoniothalami n were synthesized from tri-O-acetyl-D-glucal. and biological activities of altholactones were examined, For brine shrimp. the configuration or 3-hydr oxy group at convex site was important for lethal activity. while (2S,3S)-c onfiguration was inhibitory to lettuce germination.