Objective: Given the widely recognized genetic basis for Gilles de la Toure
tte syndrome (TS) and the suggestion that the putative TS gene(s) may be ex
pressed as or associated with a variety of psychiatric illnesses, this stud
y was undertaken to assess the prevalence of tics and TS in a psychiatric i
npatient population. Design: Cross-sectional study. Setting and patients: 2
00 consecutive adult patients who were admitted to the psychiatric wards of
University College London Teaching Hospitals. Outcome measures: TS and rel
ated behaviours, as assessed by the comprehensive semi-structured National
Hospital Interview Schedule. Results: None of the 200 patients had definite
TS, but 2 were observed to have motor tics; 10 had a history of tics (pres
ent for less than a year), and 7 reported a family history of tics. Thus, 1
9 (9.5%) inpatients qualified for inclusion in a broadly defined TS diathes
is. These rates are significantly lower than those reported in a similar co
mmunity based epidemiological study of adolescents (p = 0.018). Conclusions
: Our findings do not support the theory that TS and related behaviours are
over-represented among adult inpatients with psychiatric illnesses.