Immunofluorescence in dermatology

The accurate diagnosis of bullous and other immune diseases of the skin req uires evaluation of clinical, histologic, and immunofluorescence findings. Immunofluorescence testing is invaluable in confirming a diagnosis that is suspected by clinical or histologic examination, This is especially true in subepidermal bullous diseases that often have overlap in the clinical and histologic findings. Direct immuno fluorescence is performed oil perilesion al skin for patients with bullous diseases and lesional skin for patients w ith connective tissue diseases and vasculitis.