Regression of multifocal, skin-restricted, CD30-positive large T-cell lymphoma with interferon alfa and bexarotene therapy

We report the case of a 43-year-old male patient, vith persistent multifoca l, skin-restricted, CD30-positive, large T-cell lymphoma. Combination thera py of systemic interferon alfa and oral bexarotene was initiated on an expe rimental basis in the hope of circumventing therapies such as methothrexate , radiotherapy, or multiple-agent chemotherapy that may be required in such cases. This treatment was associated with rapid and marked regression of t he patient's Cutaneous lesions.