M. Cohen et al., Use of surgery and electron beam irradiation, with or without chemotherapy, for treatment of vaccine-associated sarcomas in cats: 78 cases (1996-2000), J AM VET ME, 219(11), 2001, pp. 1582-1589
Citations number
17
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
Objective-To evaluate responses of cats with vaccine-associated sarcomas to
treatment with surgery and radiotherapy, with or without adjunctive chemot
herapy.
Design-Retrospective study.
Animals-76 cats (78 tumors).
Procedure-Medical records were reviewed. Factors potentially associated wit
h survival time, time to recurrence, and time to development of metastases
were evaluated.
Results-Following excision, electron beam radiation, and, in some cases, ch
emotherapy, 32 (41%) cats experienced recurrence, and 9 (12%) cats develope
d metastases. One- and 2-year survival rates were 86 and 44%, respectively,
Median survival time from onset of disease was 730 days (range, 30 to 2,01
4 days). Median disease-free interval was 405 days (range, 30 to 925 days).
Cats that underwent only 1 surgery prior to radiotherapy had a lower recur
rence rate than did cats that underwent > 1 surgery and had a significantly
longer disease-free interval. Survival time and disease-free interval decr
eased as time between surgery and the start of radiotherapy increased. Cats
that developed metastases had significantly shorter survival times and dis
ease-free intervals than did cats that did not develop metastases. Castrate
d male cats had a significantly shorter survival time than did spayed femal
e cats. Cats with larger tumors prior to the first surgery had shorter surv
ival times. Twenty-six cats received chemotherapy in addition to surgery an
d radiotherapy. Whether cats received chemotherapy was not associated with
recurrence rate, metastasis rate, or survival time.
Conclusions and Clinical Relevance-Results suggest that excision followed b
y electron beam irradiation may be beneficial for treatment of cats with va
ccine-associated sarcomas. Extent of excision prior to radiotherapy did not
seem to be associated with recurrence rate.