POLAROGRAPHIC-DETERMINATION OF TEICOPLANIN

A method is proposed for the determination of Teicoplanin by different ial pulse polarography (DPP). The electroactive product was obtained b y nitration with potassium nitrate in sulphuric medium. It showed a re duction peak at -0.1 volts, which may be used for analytical purposes. The optimum conditions for the polarographic signal were determined a nd a study was made of the different parameters affecting the electroc hemical process. A polarographic procedure is proposed for the determi nation of Teicoplanin in a concentration range between 5.0x10(-6) M an d 1.4x10(-4) M. The detection limit is about 7.1x10(-7) M and the rela tive standard deviation is 3.8%. The method was applied to the determi nation of Teicoplanin in pharmaceutical formulations.