Asymmetric synthesis of beta-amino acid scaffolds

Authors
Bull, SD Davies, SG Smith, AD
Citation
Sd. Bull et al., Asymmetric synthesis of beta-amino acid scaffolds, J CHEM S P1, (22), 2001, pp. 2931-2938
Citations number
48
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
14727781 → ACNP
Issue
22
Year of publication
2001
Pages
2931 - 2938
Database
ISI
SICI code
1472-7781(2001):22<2931:ASOBAS>2.0.ZU;2-Y
Abstract
Addition of two or three equivalents of lithium (S)-N-benzyl-N-alpha -methy lbenzylamide to conjugate acceptors containing two or three alpha,beta -uns aturated ester fragments respectively and subsequent hydrogenolytic deprote ction a ord homochiral bis- or tris-beta -amino esters containing two or th ree new stereogenic centres in high de and ee.