Pyrrolidinones derived from (S)-pyroglutamic acid. Part 4. alpha,beta-diaminopyrrolidinones

Authors
Chan, PWH Cottrell, IF Moloney, MG
Citation
Pwh. Chan et al., Pyrrolidinones derived from (S)-pyroglutamic acid. Part 4. alpha,beta-diaminopyrrolidinones, J CHEM S P1, (22), 2001, pp. 3007-3012
Citations number
36
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
14727781 → ACNP
Issue
22
Year of publication
2001
Pages
3007 - 3012
Database
ISI
SICI code
1472-7781(2001):22<3007:PDF(AP>2.0.ZU;2-G
Abstract
The electrophilic amination of a beta -aminolactam, itself derived from the conjugate addition of O,N- dibenzylhydroxylamine to a highly activated alp ha,beta -unsaturated bicyclic lactam, provides direct access to conformatio nally constrained diamines. Sequential deprotection allows the synthesis of 3,4-diaminopyroglutaminols.