FLUOROMETRIC-DETERMINATION OF NALIDIXIC-ACID IN FORMULATIONS AND BIOLOGICAL-FLUIDS THROUGH TERNARY COMPLEX-FORMATION

Authors
RIZK M BELAL F ALY FA ELENANY NM
Citation
M. Rizk et al., FLUOROMETRIC-DETERMINATION OF NALIDIXIC-ACID IN FORMULATIONS AND BIOLOGICAL-FLUIDS THROUGH TERNARY COMPLEX-FORMATION, Analytical letters, 30(10), 1997, pp. 1897-1908
Citations number
19
Categorie Soggetti
Chemistry Analytical
Journal title
Analytical letters → ACNP
ISSN journal
00032719
Volume
30
Issue
10
Year of publication
1997
Pages
1897 - 1908
Database
ISI
SICI code
0003-2719(1997)30:10<1897:FONIFA>2.0.ZU;2-3
Abstract
A highly sensitive and specific fluorimetric method was developed for the determination of nalidixic acid. The proposed method involves the formation of a ternary complex with Tb3+ in the presence of hexamine. The different experimental parameters were carefully studied and incor porated into the procedure. Under the described conditions, the propos ed method is applicable over the concentration range of 0.1 - 2.4 mu g ml(-1) with a detection limit (S/N = 2) of 2 ng ml(-1). The recoverie s from spiked mine and plasma were 101.40 and 96.98 percent, respectiv ely.