MIANSERIN INDUCED HYPERTENSION 2 WEEKS AF TER DISCONTINUANCE OF TRANYLCYPROMINE

As compared to other tri- and tetracyclics, antidepressant therapy in patients suffering also from cardiac disease with mianserin is known t o be relatively safe. Hypertensive effects of mianserin have not been described so far. We report a case of a 64 years old patient with a di latative cardiomyopathy and left anterior hemiblock, who developed hyp ertension (maximum:180/125 mmHg) during mianserin treatment. Previous treatment with tranylcypromine has been stopped two weeks before. Afte r discontinuance of mianserin blood pressure rapidly came back to norm al values. The possible noradrenergic and serotonergic mechanisms of t his phenomenon are discussed in relation to pretreatment with tranylcy promine.