In vivo water quantification in mouse brain at 9.4 Tesla in a vasogenic edema model

The aim of our study was to establish a simple in vivo method for water qua ntification in vasogenic edema, and provide data on imaging of mouse brain at 9.4 Tesla. Apparent T-1 and spin density values determined by MRI were f ound to strongly correlate with the gravimetric water content of mouse brai n undergoing cold injury. Using a two-point calibration line between the sp in density values for pure water and cortex of mouse brain, as well as the corresponding water contents in vivo, water could be quantified with satisf actory accuracy. (C) 2001 Wiley-Liss, Inc.