Clinical features and treatment response of patients with major depressionand silent cerebral infarction

Previously, we reported a relationship between silent cerebral infarction ( SCI), as detected by magnetic resonance imaging (MRI), and late onset major depression. In the present study, we clarify the clinical features of the depressive phase of patients with major depression and SCI, and their respo nse to antidepressant pharmacotherapy. Using clinical charts, we retrospect ively examined patients with depression, who were first admitted for antide pressant pharmacotherapy. All patients were classified according to the MRI findings and the age on admission (older or younger than 50 years) into ei ther the young SCI(-) group (n = 23), the elderly SCI(-) group (n = 27) or the elderly SCI(+) group (n = 20). The characteristics of the clinical feat ures were evaluated at the time of admission, after 2 weeks of treatment an d at the time of discharge using the Hamilton rating scale for depression ( HAMD). These data were compared between each patient group. No differences in the clinical features, as evaluated by HAMD, were observed between the t hree groups at the time of admission. However, the mean length of treatment was significantly longer and the treatment response, as evaluated by the t otal HAMD score, was significantly worse in the elderly SCI(+) group than i n the other two groups, when examined after 2 weeks of treatment and at the time of discharge. The elderly SCI(+) group demonstrated higher scores in feelings of guilt, suicide, retardation and hypochondriasis than the young SCI(-) group and the elderly SCI(-) group after two weeks of treatment, and higher scores in early insomnia, late insomnia, somatic anxiety and hypoch ondriasis at the time of discharge. Our findings suggest that while the pre sence of SCI does not affect the clinical features observed at the time of admission, it does affect the treatment response to antidepressant pharmaco therapy. Copyright (C) 2001 S. Karger AG, Basel.