Experimental, nerve compression and upregulation of CPON in DRG

Expression of C-terminal flanking peptide of neuropeptide Y (CPON) in DRG a nd cell proliferation (incorporation of BrdU) in sciatic nerve of rats foll owing chronic nerve compression (silicone tubes with different internal dia meters) was studied by immunocytochemistry. An increased number of CPON-pos itive neurons and cells incorporating BrdU was induced on the compressed si de, most pronounced when a tight tube was used, while no cells expressed CP ON or BrdU in intact nerves. The increase was transient and declined with t ime. Nerve compression induces transient cell proliferation in the nerve an d expression of CPON in nerve cell bodies, but this is of a lesser magnitud e than those following nerve transection. NeuroReport 12:3783-3786 (C) 2001 Lippincott Williams & Wilkins.