A DECAVANADATE SANDWICHED BY DIPROTONATED CRYPTANDS-222 - MODEL FOR THE VANADATE-IONOPHORE INTERACTION

Treatment of a C222-vanadyl-AMP complex (C222 = cryptand-222, AMP = ad enosine monosphosphate) with. Me2NH in the presence of air yielded cen trosymmetric dihydrogen-decavanadate H2V10O284-, sandwiched by two dip rotonated C222 molecules. An X-ray crystal-structure analysis was perf ormed of this compound with the overall composition [C222(H+)(2)](2)[H 2V10O28]. 2 1/2 H2O. Protonation sites in the anion are mu(2)-oxygen a toms linking two different vanadium centres. Protonation sites at the cryptand are the nitrogen and/or oxygen atoms of one of the -[CH2](2)O [-CH2](2)O[CH2](2)- bridges. The relevance of the compound for the sta bilisation and transport of the kinase and phosphatase inhibitor decav anadate by biogenic ionophores is addressed.