The value of immunoscintigraphy in the detection of recurrent colorectal cancer

Citation
F. Baulieu et al., The value of immunoscintigraphy in the detection of recurrent colorectal cancer, NUCL MED C, 22(12), 2001, pp. 1295-1304
Citations number
34
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging
Journal title
NUCLEAR MEDICINE COMMUNICATIONS
ISSN journal
01433636 → ACNP
Volume
22
Issue
12
Year of publication
2001
Pages
1295 - 1304
Database
ISI
SICI code
0143-3636(200112)22:12<1295:TVOIIT>2.0.ZU;2-I
Abstract
The aim of this prospective study was to determine whether anti-carcinoembr yonic antigen (anti-CEA) scintigraphy is a useful additional technique in t he diagnosis recurrence of colorectal cancer. Forty patients with suspected recurrence of colorectal cancer, underwent immunoscintigraphy (IS) and hel ical computed tomography (CT) in the 2 weeks before surgery. Surgical findi ngs were used to evaluate the performance of the imaging techniques. Suspec ted areas on IS and CT were systematically explored. Helical CT was found t o be superior to IS for the liver, the sensitivity and specificity of CT be ing 100% and 90%, respectively, vs 53% and 100% for IS. However, IS was bet ter than CT for the detection of extra-hepatic abdominal recurrence: sensit ivity and specificity of IS were 100 and 82%. respectively vs 33 and 82% fo r CT. Seven cases of peritoneal carcinomatosis were overlooked by helical C T. Our results indicate that IS improves detection of extra-hepatic abdomin al recurrence of colorectal cancer. Immunoscintigraphy is valuable as a gui de to the treatment strategy and operative procedures. ((C) 2001 Lippincott Williams & Wilkins).