Intermolecular hydroamination of terminal alkynes catalyzed by organoactinide complexes. Scope and mechanistic studies

Organoactinide complexes of the type CP*(2)AnMe(2) (An = Th, U) have been f ound to be efficient catalysts for the hydroamination of terminal alkynes w ith aliphatic primary amines. The chemoselectivity and regioselectivity of the reactions depend strongly on the nature of the catalyst and the nature of the amine and show no major dependence on the nature of the alkyne. The hydroamination reaction of the terminal alkynes with aliphatic primary amin es catalyzed by the organouranium complexes produces the corresponding imin es where the amine and the alkyne are regioselectively disposed in a syn-re giochemistry, whereas for similar reactions with the organothorium complex besides the methyl alkylated imine, dimeric and trimeric alkyne oligomers a re also produced. For (TMS)C drop CH, and EtNH2 both organoactinides produc ed the same imine compounds when the reaction is carried out in THF or tolu ene. In benzene, both imines E and Z (TMS)CH2CHN=Et are obtained, the earli er undergo a 1,3-silyl Brook sigmatropic rearrangement toward the enamine, whereas the latter remains unchanged. Mechanistic studies on the hydroamina tion of (TMS)C drop CH and EtNH2 promoted by the organouranium complex show that the first step in the catalytic reaction is the formation of the bis( amido) complex, found in equilibrium with the corresponding bisamido-amine complex, which loses an amine, yielding a uranium-imido complex. Insertion of the alkyne into the imido bond with subsequent amine protonolysis, isome rization, and product release comprise the primary steps in the catalytic c ycle. The kinetic rate law was found to follow an inverse kinetic order in amine, a first order in complex, and a zero order in alkyne, with DeltaH(do uble dagger) = 11.7(3) kcal mol(-1), DeltaS(double dagger) = -44.5(8) eu. T he turnover-limiting step is the release of an amine from the bisamido comp lex yielding the imido complex. The key organoactinide intermediate for the intermolecular hydroamination reaction was found to be the corresponding a ctinide-imido complexes. For both actinides the complexes have been charact erized, and for thorium the single-crystal X-ray diffraction was studied. A plausible mechanistic scenario is proposed for the hydroamination of termi nal alkynes and aliphatic primary amines.