SEMAX EFFICIENCY IN ACUTE PERIOD OF HEMIS PHERICAL ISCHEMIC STROKE (CLINICAL AND ELECTROPHYSIOLOGICAL STUDY)

Efficiency of Semax (synthetic derivative of ACTH-4-10) was studied in 30 patients in acute period of hemispherical ischemic stroke, Control group consisted of 80 patients with the strokes analogous in severity and location of the damages and which were treated by conventional th erapy. Different clinical rating scales were used for both objectiviza tion of the severity of the patients' state and estimation of the degr ee of neurological defect, The control of Semax influence on the funct ional state of the brain included monitoring of EEG with mapping, repe ated analysis of somatosensory evoked potentials and their mapping. It was established that including of Semax in combined intensive therapy of acute ischemic stroke had some influence on the rate of restoratio n of the damaged neurological functions in terms of increasing the reg ress of general cerebral and focal, especially motor disorders,The mos t effective daily doses were 12 mg for patients with strokes of modera te severity and 18 mg for patients with severe strokes (treatment cour se-5 and 10 days).