AUTOANTIBODIES TO NMDA-TYPE GLUTAMATE REC EPTORS IN THE BLOOD OF PATIENTS WITH ACUTE ISCHEMIC AND HEMORRHAGIC STROKE

The characteristics of accumulation of autoantibodies (aAbs) on NMDA-t ype glutamate receptors were studied in blood of patients at different stages (1-4 days, 5-7 days, 8-14 days, up to 28 days) of acute period of ischemic or hemorrhagic stroke. The stability of low values (1,29 +/- 0,31 ng/ml) of the titer of aAbs to NMDA-receptors was revealed in patients with acute cerebral hemorrhage. Two types of filter of Abs t o NMDA-receptors were revealed in case with cerebral ischemia. The und ulating nature of Abs titer changes was revealed in acute ischemic str okes caused by hypertension and cerebral atherosclerosis (from 2,23 +/ - 0,53 ng/ml on the 1-st day with increase up to 3,23 +/- 0,90 ng/ml a nd up to the 3-4 day), following fluctuations with less pronounced inc rease on 7-8th day were found out. High titer of aAbs to NMDA-receptor s (up to 10,0 ng/ml) were observed; on 3-4th day in cases of acute isc hemic strokes on the background of chronic alcohol encephalopathy caus ed by intoxication or dismetabolism with their retention up to 10-14th day.